2017.11.06 / Monday
Neuroleptic Malignant Syndrome and Summary of Body Temperature Disorders
About Neuroleptic Malignant Syndrome:
NMS is a rare specific reaction to Phenothiazine and Butyrophenone, which may be associated with the central dopamine -2 receptor block. The main manifestations of the NMS are the increase of muscular tension, akinesias, and the extrapyramidal symptoms such as tremor. At the same time, there may be autonomic nervous dysfunction, rhabdomyolysis, acute live/ renal failure and other symptom.
A common drug that causes NMS:
All drugs that block the dopamine -2receptor may induce NMS
Studies show that large dose, rapid and non-intestinal drug use can induce NMS
Patients with NMS were once again treated with neuroleptic, and 30% of patients could relapse
These include Thioxanthene, Phenothiazine, Butyrophenones, other antipsychotucs, and Anti-parkinson’s disease syndrome.
It should be noted that:
When the body core temperature ＜ 30℃, taboo external heat
Moderate fever is good for the body, ＜40℃ generally doesn’t need to cool
The cooling effect of evaporation is good (peripheral blood tube is not easy to shrink)
Treatment of MH, specific medicine: Dantrolene
Treatment of NMS is Dantrolene and Bromocriptine
Corresponding to this series of body temperature disorders, it can draw the following conclusions:
Body temperature disorders should be taken seriously.
Use the skin surface temperature sensor or general purpose temperature probe(body cavity: esophageal temperature probe or rectal temperature probe) to monitor the body deep temperature of the sane area.