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The Possible Effects of Therapeutic Hypothermia on the Body​

2019.05.31 / Friday

The Possible Effects of Therapeutic Hypothermia on the Body



If properly and make full use of therapeutic hypothermia, then will be something good for patients, but because when the body is about 37 ℃ and PH7.4 slightly, the dynamics of the organization and the chemical characteristics of autonomous optimization, playing the best utility to each other, so cut the body core temperature a few degrees almost changed the body each organs physiological function of the system.


Studies have shown that hypothermia may cause a linear decrease in heart rate and cardiac output, consistent with a decrease in metabolic rate, and that these are physiological changes rather than pathological ones.


In fact, hypothermia may also weaken the effects of cardiotropic drugs and shift the response away from the b-adrenergic (myocardial contractility) effect to the peripheral alpha-adrenergic (vasoconstriction) effect.

As body temperature drops and the body's metabolic rate drops, so does the production of carbon dioxide.

Meanwhile, the dissolution rate of carbon dioxide in the blood will increase, which will directly lead to the decrease of pco2, and then affect the cerebral blood flow.

In addition, a decrease in pco2 is likely to cause alkalosis and increase the risk of seizures.

Immunity will also be reduced, and the incidence of coagulation disorders and glucose metabolism changes due to low temperature may also increase. However, these possible conditions are largely affected by the severity of hypoxia injury, which needs to be better understood by medical staff.


Also, metabolism and clearance of many commonly used drugs can be slowed throughout hypothermia therapy, and clinicians need to be careful about these traps.

During the whole process of  therapeutic hypothermia, it is necessary to use a medical temperature probe to monitor the patient's temperature, pay attention to the temperature changes at all times, and try to avoid the occurrence of various hypothermia sequelae.


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