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General Definition and Diagnosis Method of Drug Induced Fever

2018.12.21 / Friday

General Definition and Diagnosis Method of Drug Induced Fever


Drug Fever

Drug induced fever refers to fever caused directly or indirectly by the use of drugs. As antigens or haptens, drugs trigger an immune response and stimulate endogenous pyrogen release, resulting in fever.

It's essentially an adverse reaction to a drug.

However, drug fever is not easy to be judged clinically. The diagnosis of drug fever is often an exclusion diagnosis. The possibility of drug fever can only be considered if all other possible causes of fever are excluded.


Laboratory examination of drug fever has no specificity and cannot be used as the diagnostic standard of drug fever, but can be used as an auxiliary diagnostic or exclusion method.

The following are four drug thermal diagnosis methods for reference:

1. In patients with fever type diagnosed as infective fever, after the application of antibiotics, the medical temperature probe data feedback that the temperature of the patients has decreased, but continue to use the drug, the temperature rises again.

2. Those who have been diagnosed as infectious fever have a higher body temperature after the application of antibiotics than before, and some of them can be traced back to the same history of fever after the application of antibiotics;

3. Fever or increased body temperature cannot be explained by the original infection, and there is no evidence of secondary infection. Although the patient has high fever, he is in good physical condition;

4. The body temperature drops rapidly after stopping the suspicious drug, and then heats up again with the same drug.

Drug fever can be diagnosed if it is in accordance with article 4 above and any of the other conditions accompanied or not accompanied by other allergic reactions such as rashes.